Mme Carole COSSU-LEGUILLE
Professeur
Laboratoire Interdisciplinaire des Environnements Continentaux
UMR 7360 CNRS - Université de Lorraine

Campus Bridoux, Bât. IBISE, 8 rue du Général Delestraint
57070 METZ, FRANCE

Tel :       +33(0)3 72 74 89 73
Fax :     +33(0)3 72 74 89 74
e-mail : carole.leguille(@)univ-lorraine.fr

Responsabilités administratives
Enseignant - Chercheur
Responsable du Master Environnement Ecotoxicologie Ecosystèmes et de la spécialité Ecotoxicologie et Ecologie des Systèmes Anthropisés
 
Thématiques de recherche
Développement et validation de biomarqueurs de défenses antitoxiques chez des invertébrés d'eau douce (Unio tumidus, Corbicula fluminea, Dreissena polymorpha, Gammarus sp.) comme outils prédictifs de la qualité des systèmes aquatiques
 
Enseignements / Encadrements
Ecotoxicologie - Toxicologie - Outils bio-analytiques - Evaluation des risques pour l\'Homme et l'Environnement - Physiologie animale
 
Domaines de compétences
Ecotoxicologie - Enzymologie - Chromatographie Liquide Haute Performance
 
Divers
Membre titulaire de la commission de spécialistes de l'université Paul Verlaine de Metz
 

Publications
  • Publications internationales

PARANT M., SOHM B., FLAYAC J., PERRAT E., CHUBURU F., CADIOU C., ROSIN C., COSSU-LEGUILLE C., 2019. Impact of gadolinium-based contrast agents on the growth of fish cells lines. Ecotoxicology And Environmental Safety 182     .  [doi]

ROMERO-FREIRE A., JOONAS E., MUNA M., COSSU-LEGUILLE C., VIGNATI D., GIAMBÉRINI L., 2019. Assessment of the toxic effects of mixtures of three lanthanides (Ce, Gd, Lu) to aquatic biota. Science Of The Total Environment 661, 276-284     Réf. HAL: hal-01990037.  [doi]

KOEHLE-DIVO V., COSSU-LEGUILLE C., PAIN-DEVIN S., SIMONIN C., BERTRAND C., SOHM B., MOUNEYRAC C., DEVIN S., GIAMBÉRINI L., 2018. Genotoxicity and physiological effects of CeO2 NPs on a freshwater bivalve (Corbicula fluminea) Aquatic Toxicology 198, 141-148.  [doi]

PARANT M., PERRAT E., WAGNER P., ROSIN C., PY J.-S., COSSU-LEGUILLE C., 2018. Variations of anthropogenic gadolinium in rivers close to waste water treatment plant discharges. Environmental Science And Pollution Research 25, 36207-36222.  [doi]

PERRAT E., PARANT M., PY J.-S., ROSIN C., COSSU-LEGUILLE C., 2017. Bioaccumulation of gadolinium in freshwater bivalves Environmental Science And Pollution Research 24 (13), 12405-12415.  [doi]

ARCE-FUNCK J., CRENIER C., DANGER M., COSSU-LEGUILLE C., GUÉROLD F., FELTEN V., 2016. Stoichiometric constraints modulate impacts of silver contamination on stream detritivores: an experimental test with Gammarus fossarum Freshwater Biology 61 (12), 2075-2089.  [doi]

GARAUD M., TRAPP J., DEVIN S., COSSU-LEGUILLE C., PAIN-DEVIN S., FELTEN V., GIAMBÉRINI L., 2015. Multibiomarker assessment of cerium dioxide nanoparticle (nCeO(2)) sublethal effects on two freshwater invertebrates, Dreissena polymorpha and Gammarus roeseli. Aquatic Toxicology 158, 63-74.  [doi]

MINGUEZ L., DI POI C., FARCY E., BALLANDONNE C., BENCHOUALA A., BOJIC C., COSSU-LEGUILLE C., COSTIL K., SERPENTINI A., LEBEL J.-M., HALM-LEMEILLE M.-P. , 2014. Comparison of the sensitivity of seven marine and freshwater bioassays as regards antidepressant toxicity assessment. Ecotoxicology 23, 1744-1754..  [doi]

PAIN-DEVIN S., COSSU-LEGUILLE C., GEFFARD A., GIAMBÉRINI L., JOUENNE T., MINGUEZ L., NAUDIN B., PARANT M., RODIUS F., ROUSSELLE P., TARNOWSKA K., DAGUIN-THIEBAUT C., VIARD F., DEVIN S. , 2014. Towards a better understanding of biomarker response in field survey: A case study in eight populations of zebra mussels. Aquatic Toxicology 155, 52-61..  [doi]

ARCE FUNCK J., DANGER M. GISMONDI E., COSSU-LEGUILLE C., GUÉROLD F., FELTEN V. , 2013. Behavioural and physiological responses of Gammarus fossarum (Crustacea Amphipoda) exposed to silver. Aquatic Toxicology 142-143, 73-84..  [doi]

BOURGEAULT A., CIFFROY P., GARNIER C., COSSU-LEGUILLE C., MASFARAUD J.-F., CHARLATCHKA R., GARNIER J.-M. , 2013. Speciation and bioavailability of dissolved copper in different freshwaters: Comparison of modelling, biological and chemical responses in aquatic mosses and gammarids. Science Of The Total Environment 452, 68-77..  [doi]

GISMONDI E., COSSU-LEGUILLE C., BEISEL J.-N. , 2013. Do male and female gammarids defend themselves differently during chemical stress?. Aquatic Toxicology 140, 432-438..  [doi]

TILMANT K., GERETS H.-H.-J., DE RON P., COSSU-LEGUILLE C., VASSEUR P., DHALLUIN S., ATIENZAR F.-A. , 2013. The automated micronucleus assay for early assessment of genotoxicity in drug discovery. Mutation Research-Genetic Toxicology And Environmental Mutagenesis 751, 1-11..  [doi]

GISMONDI E., BEISEL J.-N., COSSU-LEGUILLE C., 2012. Influence of gender and season on reduced glutathione concentration and energy reserves of Gammarus roeseli. Environmental Research, 118: 47-52.  [doi]

GISMONDI E., BEISEL J.-N., COSSU-LEGUILLE C., 2012. Polymorphus minutus affects antitoxic responses of Gammarus roeseli exposed to cadmium. PLoS ONE, 7 (7): e41475.  [doi]

GISMONDI E., COSSU-LEGUILLE C., BEISEL J.-N., 2012. Does the acanthocephalan parasite Polymorphus minutus modify the energy reserves and antitoxic defences of its intermediate host Gammarus roeseli? Parasitology, 139: 1054-1061.  [doi]

GISMONDI E., COSSU-LEGUILLE C., BEISEL J.-N., 2012. Acanthocephalan parasites: help or burden in gammarid amphipods exposed to cadmium? Ecotoxicology, 21 (4): 1188-1193.  [doi]

GISMONDI E., RIGAUD T., BEISEL J.-N., COSSU-LEGUILLE C., 2012. Microsporidia parasites disrupt the responses to cadmium exposure in a Gammarid. Environmental Pollution, 160 (1): 17-23.  [doi]

GISMONDI E., RIGAUD T., BEISEL J.-N., COSSU-LEGUILLE C., 2012. Effect of multiple parasitic infections on the tolerance to pollutant contamination. PLoS ONE, 7 (7): e41950.  [doi]

DEBLONDE T., COSSU-LEGUILLE C., HARTEMANN P., 2011. Emerging pollutants in wastewater: A review of the literature. International Journal of Hygiene and Environmental Health, 214 (6): 442-446.  [doi]

SRODA S., COSSU-LEGUILLE C., 2011. Effects of sublethal copper exposure on two gammarid species: which is the best competitor? Ecotoxicology, 20 (1): 264-273.  [doi]

SRODA S., COSSU-LEGUILLE C., 2011. Seasonal variability of antioxidant biomarkers and energy reserves in the freshwater gammarid Gammarus roeseli. Chemosphere, 83 (4): 538-544.  [doi]

TILMANT K., GERETS H.H.J., DHALLUIN S., HANON E., DEPELCHIN O., COSSU-LEGUILLE C., VASSEUR P., ATIENZAR F., 2011. Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis. Toxicology in Vitro, 25 (7): 1414-1424.  [doi]

BIGORGNE E., COSSU-LEGUILLE C., BONNARD M., NAHMANI J., 2010. Genotoxic effects of nickel, trivalent and hexavalent chromium on the Eisenia fetida earthworm. Chemosphere, 80 (9): 1109-1112.  [doi]

COFFINET S., COSSU-LEGUILLE C., BASSÈRES A., GONNET J.-F., VASSEUR P., 2008. Response of the bivalve Unio tumidus and freshwater communities in artificial streams for hazard assessment of methyl methacrylate. Environmental Toxicology and Chemistry, 27 (6): 1371-1382.  [doi]

COFFINET S., COSSU-LEGUILLE C., RODIUS F., VASSEUR P., 2008. Glutamate cysteine ligase (GCL) in the freshwater bivalve Unio tumidus: impact of storage conditions and seasons on activity and identification of partial coding sequence of the catalytic subunit. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 151 (1): 88-95.  [doi]

COFFINET S., COSSU-LEGUILLE C., BASSÈRES A., GONNET J.-F., VASSEUR P., 2006. Artificial streams in the assessment of environmental hazard of chemicals. Environmental Toxicology, 21 (5): 450-456.  [doi]

VASSEUR P., COSSU-LEGUILLE C., 2006. Linking molecular interactions to consequent effects of persistent organic pollutants (POPs) upon populations. Chemosphere, 62 (7): 1033-1042.  [doi]

GIGUÈRE A., CAMPBELL P.G.C., HARE L., COSSU-LEGUILLE C., 2005. Metal bioaccumulation and oxidative stress in yellow perch (Perca flavescens) collected from eight lakes along a metal contamination gradient (Cd, Cu, Zn, Ni). Canadian Journal of Fisheries and Aquatic Sciences, 62 (3): 563-577.

LEMIÈRE S., COSSU-LEGUILLE C., BISPO A., JOURDAIN M.-J., LANHERS M.-C., BURNEL D., VASSEUR P., 2005. DNA damage measured by the single-cell gel electrophoresis (Comet) assay in mammals fed with mussels contaminated by the 'Erika' oil-spill. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 581 (1-2): 11-21.  [doi]

LEMIÈRE S., COSSU-LEGUILLE C., CHARISSOU A.-M., VASSEUR P., 2005. DNA damage (comet assay) and 8-oxodGuo (HPLC-EC) in relation to oxidative stress in the freshwater bivalve Unio tumidus. Biomarkers, 10 (1): 41-57.

CHARISSOU A.-M., COSSU-LEGUILLE C., VASSEUR P., 2004. Relationship between two oxidative stress biomarkers, malondialdehyde and 8-oxo-7,8-dihydro-2'-deoxyguanosine, in the freshwater bivalve Unio tumidus. Science of the Total Environment, 322 (1-3): 109-122.  [doi]

LEMIÈRE S., COSSU-LEGUILLE C., BISPO A., JOURDAIN M.-J., LANHERS M.-C., BURNEL D., VASSEUR P., 2004. Genotoxicity related to transfer of oil spill pollutants from mussels to mammals via food. Environmental Toxicology, 19 (4): 387-395.  [doi]

LEMIÈRE S., COSSU-LEGUILLE C., CHATY S., RODIUS F., BISPO A., JOURDAIN M.-J., LANHERS M.-C., BURNEL D., VASSEUR P., 2004. Genotoxic and CYP 1A enzyme effects consecutive to the food transfer of oil spill contaminants from mussels to mammals. Aquatic Living Resources, 17: 303-307.  [doi]

VASSEUR P., COSSU-LEGUILLE C., 2003. Biomarkers and community indices as complementary tools for environmental safety. Environment International, 28 (8): 711-717.  [doi]

CHATY S., LEMIÈRE S., COSSU-LEGUILLE C., RODIUS F., BISPO A., JOURDAIN M.-J., LANHERS M.-C., BURNEL D., VASSEUR P., 2002. Food contamination transfer of Erika pollutants from mussels to mammals, Les évaluations des suites du naufrage de l'Erika. IFREMER, Nantes, 23-25 janvier 2002..

COSSU-LEGUILLE C., DOYOTTE A., BABUT M., EXINGER A., VASSEUR P., 2000. Antioxidant biomarkers in freshwater bivalves, Unio tumidus, in response to different contamination profiles of aquatic sediments. Ecotoxicology and Environmental Safety, 45 (2): 106-121.  [doi]

BESSI H., COSSU-LEGUILLE C., ZAID A., VASSEUR P., 1999. Effects of chlorothalonil on glutathione and glutathione-dependent enzyme activities in Syrian hamster embryo cells. Bulletin of Environmental Contamination and Toxicology, 63 (5): 582-589.  [doi]

COSSU-LEGUILLE C., DOYOTTE A., BABUT M., EXINGER A., VASSEUR P., 1999. Responses of antioxidant parameters and lipid peroxidation in freshwater bivalves, Unio tumidus, exposed to different contamination profiles of aquatic sediments, pp. O G4-1-2. SECOTOX 99 - 5th European conference on Ecotoxicology and environmental safety. Münich, Germany, 15-17 March 1999..